The body’s own peptide rose.
The cycling study measured endogenous MOTS-c in muscle and serum after cycling.
MOTS-c
Where exercise and metabolism meet.
A peptide made inside mitochondria, studied in exercise and metabolism.
$359/month
Written into mitochondrial DNA
16 aaA peptide with an unusual address.
MOTS-c comes from a short open reading frame within mitochondrial 12S rRNA. It has been detected in human skeletal muscle and blood.
See the full evidence breakdown →AMPK and glucose transport
How the proposed pathway moves through muscle.
Cell and mouse experiments connect MOTS-c with AICAR accumulation, AMPK activation, and GLUT4 movement toward the muscle-cell membrane.
Read the pathway paper ↗
AICARmetabolic intermediate
AMPKcellular energy sensor
GLUT4muscle glucose transporter
Human exercise study
Muscle and serum rose after one cycling session.
A study measured endogenous MOTS-c in 10 young men before and after stationary-bike exercise. The peptide increased in skeletal muscle and serum.
10participants
2sample types
↑muscle and serum
Before you decide
Know which MOTS-c story you are reading.
The evidence runs from the body’s own exercise signal to animal treatment experiments and a recruiting 120-person human trial.
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Capacity was measured across ages.
Mouse studies tested treatment against treadmill and physical-capacity endpoints.
A 30 mg cartridge is planned.
The product guide covers substance, concentration, directions, price, storage, and supply.
MOTS-c product details
Formula, directions, supply, and launch status.
MOTS-c evidence
Mitochondrial signaling, exercise, and metabolic studies.
Product details
Formula, directions, supply, storage, and injection route.
Injection details
Read the directions, storage, supply, and pharmacy details.
Mouse physical-capacity studies
Longer treadmill time and distance across three ages.
Acute intraperitoneal MOTS-c treatment improved treadmill performance in young, middle-aged, and old mice. Separate late-life experiments measured grip strength, gait, walking, body composition, and physical capacity after intermittent treatment.
2 mo young12 mo middle-aged22 mo old
Read the animal study ↗Human treatment study
A 120-person randomized trial is recruiting.
A planned 120-person Phase 2a trial will compare subcutaneous MOTS-c with placebo for 12 weeks in adults with prediabetes and overweight or obesity, measuring insulin sensitivity and metabolic markers.
120 planned enrollment1:1 active or placebo12 wk treatment
View the registered trial ↗Planned MOTS-c pen
30 mg in one 3 mL cartridge.
The planned prescription uses a reusable pen. The cartridge contains 30 mg total at 10 mg/mL. The prescribed routine is 12 units under the skin, Monday through Friday, with 25 doses each month.
- Format
- Reusable pen + 3 mL cartridge
- Strength
- 10 mg/mL · 30 mg total
MOTS-c updates
More on MOTS-c.
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