The body’s own peptide rose.
The cycling study measured endogenous MOTS-c in muscle and serum after cycling.
MOTS-c
Where exercise and metabolism meet.
The body makes MOTS-c inside mitochondria. Exercise raised the endogenous peptide in skeletal muscle and blood in a study of 10 young men completing a stationary-bike session.
Written into mitochondrial DNA
16 aaA peptide with an unusual address.
MOTS-c comes from a short open reading frame within mitochondrial 12S rRNA. It has been detected in human skeletal muscle and blood.
See the full evidence breakdown →AMPK and glucose transport
How the proposed pathway moves through muscle.
Cell and mouse experiments connect MOTS-c with AICAR accumulation, AMPK activation, and GLUT4 movement toward the muscle-cell membrane.
Read the pathway paper ↗
AICARmetabolic intermediate
AMPKcellular energy sensor
GLUT4muscle glucose transporter
Human exercise study
Muscle and serum rose after one cycling session.
A study measured endogenous MOTS-c in 10 young men before and after stationary-bike exercise. The peptide increased in skeletal muscle and serum.
10participants
2sample types
↑muscle and serum
Before you decide
Know which MOTS-c story you are reading.
The evidence runs from the body’s own exercise signal to animal treatment experiments and a recruiting 120-person human trial.
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Capacity was measured across ages.
Mouse studies tested treatment against treadmill and physical-capacity endpoints.
A 10 mg vial is planned.
The product guide covers substance, concentration, directions, price, storage, and supply.
MOTS-c product details
Formula, directions, price, and supply.
MOTS-c evidence
Mitochondrial signaling, exercise, and metabolic studies.
Product details
Formula, directions, price, supply, storage, and injection route.
Injection details
Read the directions, storage, supply, and pharmacy details.
Mouse physical-capacity studies
Longer treadmill time and distance across three ages.
Acute intraperitoneal MOTS-c treatment improved treadmill performance in young, middle-aged, and old mice. Separate late-life experiments measured grip strength, gait, walking, body composition, and physical capacity after intermittent treatment.
2 mo young12 mo middle-aged22 mo old
Read the animal study ↗Human treatment study
A 120-person randomized trial is recruiting.
A planned 120-person Phase 2a trial will compare subcutaneous MOTS-c with placebo for 12 weeks in adults with prediabetes and overweight or obesity, measuring insulin sensitivity and metabolic markers.
120 planned enrollment1:1 active or placebo12 wk treatment
View the registered trial ↗Planned MOTS-c injection
A planned 10 mg injection vial.
The planned MOTS-c prescription would be filled by a licensed U.S. compounding pharmacy. The patient-specific label identifies the substance, concentration, directions, storage, and beyond-use date.
- Format
- Injection vial
- Planned amount
- 10 mg
MOTS-c updates
More on MOTS-c.
Keep the evidence, formulation, price, and practical questions in one Rebody account.