Stage 01 · The signalA nudge to the pituitary
Sermorelin binds GHRH receptors on the pituitary's somatotroph cells and tells them to fire — the same trigger your own hypothalamus uses, just reinforced.
Growth hormone works while you sleep.
Sermorelin at bedtimePrescription GHRH peptide · three formats
Sleep that gives something back.
- A bedtime Sermorelin routine built around sleep that carries into tomorrow.
- Choose the format you will actually keep using: injection, nasal spray, or under-the-tongue troche.
- Your first month includes the online visit, a monthly supply if prescribed, discreet shipping, and follow-up messaging.
First month50% off
$159$79.50/first mo.
Choose your format
Injection · Nasal · Troche
What happens next
5-minute visit → review → delivery if prescribed
Start your online visit
FSA & HSA eligibleUse eligible benefit funds
Split your payment into interest-free installments with Klarna at checkout.
Free discreet shipping
Filled by a licensed U.S. compounding pharmacy
US-licensed providers
See each format for its supply and routine. See full pricing →
Best for
Adults exploring a bedtime Sermorelin routine for sleep or recovery goals who want injection, nasal spray, and troche formats shown with their real tradeoffs.
For men and women
Bedtime routine
Sleep and recovery goals
Pituitary-led release
IGF-1 can be measured
Injection option
Needle-free nasal spray
Under-tongue troche
Prescription-only
Individual response varies
Available formats
Choose injection, spray,
or troche.
Injection, nasal spray, and troches differ by price, dose flexibility, routine, storage, travel, supply, and follow-up needs.
Injectable
$109.50 first mo.
Subcutaneous injection with syringe prep, storage, and dose timing set by the prescription.
Nasal spray
$79.50 first mo.
Needle-free metered spray routine with a 6 mL monthly supply and no syringe prep.
Sublingual troches
$79.50 first mo.
Dissolves under the tongue when a nightly mouth-dissolve routine is easier than sprays or injections.
A bedtime routine for sleep and recovery goals.
Sermorelin — mechanism, format, price, and response kept separate
How Growth Hormone peptides work
From your first dose to full systemic benefits — here’s exactly what happens inside your body at each stage of the process.
Bedtime dose
A prescribed dose timed around your natural nighttime growth-hormone release.
Pituitary activation
The peptide signals your pituitary gland—the master regulator of hormones—to release growth hormone in natural pulses.
GH → IGF-1 conversion
Growth hormone travels to your liver and triggers the production of IGF-1 (insulin-like growth factor), the molecule responsible for most of GH’s downstream benefits.
Response over time
IGF-1 and symptoms can be followed over time. Older-adult GHRH analog studies raised IGF-1, but sleep and body-composition effects were mixed.
Why it matters with age
Your growth hormone fades with age.
Your pituitary keeps working, but the nightly growth-hormone pulses shrink decade by decade — one reason sleep, recovery, and body composition tend to drift as you get older. Sermorelin works one step upstream to nudge that rhythm back up.
Check your eligibility
Growth-hormone release starts at the pituitary
- Synthetic HGH supplies growth hormone from outside; Sermorelin signals the pituitary one step upstream.
- Sermorelin prompts your pituitary to release growth hormone in the natural nightly pulses your body already uses.
- Sleep, recovery, body composition, and side effects still need to be tracked on their own. Individual results vary.¹²
The biology, up close
What's happening inside the cell.
Sermorelin works one signal upstream, prompting pituitary release through the same GHRH receptor pathway your body already uses. Here's the chain from the pituitary to the tissue.
Stage 01 · The signal
Stage 02 · The releaseGrowth hormone, in pulses
Those cells release growth hormone in short bursts into your bloodstream — a pulsatile rhythm, concentrated at night, that your feedback loop keeps in check.
Stage 03 · The payoffIGF-1 at your tissues
Growth hormone signals the liver to produce IGF-1, a measurable marker of the growth-hormone axis. Sleep, body composition, and recovery remain separate outcomes to track.
Track the marker and the outcome
IGF-1 can move before your nights feel different.
IGF-1 is the growth-hormone marker your provider can actually measure. In a placebo-controlled trial of a GHRH(1–29) analog — the same class as sermorelin — serum IGF-1 rose meaningfully over 16 weeks, while it stayed flat on placebo.
In that older-adult trial, sleep quality was unaffected. Track the lab marker, sleep, recovery, side effects, and body-composition changes as separate outcomes.³
Check your eligibility↑ 28%Higher IGF-1 (a growth-hormone marker) on sermorelin in trials
One step, right before bed.
Sermorelin fits into the moment you're already in — a quick dose at bedtime, timed to your body's own nighttime growth-hormone release. No mid-day planning, no complicated routine to keep up.
Check your eligibilityGHRH peptides vs. synthetic HGH
RebodySermorelin
Synthetic HGH
Where the growth hormone comes fromThe source of the hormone in your body.
Your own pituitary
Injected from outside
Release patternHow the hormone moves through your day.
Pituitary-mediated pulses
Hormone delivered from outside
Your feedback loopWhether your body keeps self-regulating.
Remains part of the response
Bypassed by replacement hormone
RoutineWhat it actually looks like day to day.
Bedtime dose — 3 formats
Daily injections
Side-effect profileRelative risk of the common issues.
Route- and dose-dependent risks
A different risk profile
What the extra growth hormone actually does.
A bedtime routine built around your sleep
Recovery goals you can track over time
IGF-1 and symptoms, measured separately
It's easy to get started.
01
Share what you want to improve
Tell a licensed provider about your goals, 100% online.
02
Get a science-led plan
A licensed provider recommends a protocol tailored to you.
03
Delivered to your door
If prescribed online, your treatment ships free in discreet packaging.
04
Adjust when you need to
Dose changes as your needs evolve, with no added fee.
Start your online visit
Share sleep timing, fatigue pattern, medications, diagnoses, prior treatment use, and whether injection, nasal spray, or troches match your routine.
Start your online visitfrom$79.50/first mo.50% offSplit your payment into interest-free installments with Klarna at checkout.
Growth-hormone peptide FAQs
Contact support →What are growth-hormone peptides, and how do they work?
Sermorelin is a GHRH peptide — a secretagogue. Instead of supplying growth hormone from outside, it signals the pituitary to release growth hormone. That mechanism is different from HGH replacement, but it does not guarantee better sleep, recovery, fat loss, or body-composition changes.
How is this different from synthetic HGH?
Synthetic HGH supplies growth hormone from outside. Sermorelin acts one step upstream by signaling the pituitary. The products, evidence, dosing, and risks are different, so one should not be presented as a safer equivalent of the other.
When will I notice a change?
There is no reliable timetable for a felt change. In an older-adult GHRH analog trial, IGF-1 increased but sleep quality did not improve. Track sleep, recovery, side effects, and any ordered labs separately rather than assuming a higher IGF-1 means you should feel different.
Which format is right for me — injection, nasal spray, or troche?
The injection offers the most dose flexibility. The nasal spray and under-the-tongue troche keep the routine needle-free. Your provider helps you choose based on your sleep timing, medications, and what you'll realistically keep up each night.
Do I need a prescription?
Yes. Sermorelin is prescription-only. When you finish your online visit, a licensed provider reviews your health profile and decides whether it's a good fit. If approved, your prescription is sent to a licensed US compounding pharmacy and shipped to you — no in-person visit required.
How do I take the injection?
It's a small subcutaneous injection just under the skin, usually in the upper outer thigh, taken at bedtime to line up with your body's natural nighttime growth-hormone release. Most people describe it as nearly painless. Full directions and message-based support come with your protocol.
Care you can trust, on your nightstand.
Sermorelin in your chosen format, with the first month starting at $79.50, licensed pharmacy fulfillment, and a care team you can message.
- Online visits from your phone
- US-licensed medical providers
- LegitScript-certified Rebody platform
- Free discreet shipping
What to know about side effects
Sermorelin works through your body's own feedback loops. Reported effects are often mild and may ease as your body adjusts, while persistent or serious symptoms need prompt follow-up.
This is not a complete list. Message your care team with any questions.
Most common
- Injection-site redness, itching, or swelling
- Headache
- Flushing or lightheadedness
- Temporary water retention
- Nasal irritation (nasal spray)
- Odd taste (troche)
Less common — tell your provider
- Persistent joint pain or stiffness
- Marked swelling or fluid retention
- Signs of high blood sugar — unusual thirst or frequent urination
- Allergic reaction: rash, itching, or swelling
Important: Growth-hormone peptides are not for anyone with active or a history of cancer, during pregnancy or breastfeeding, or under 18. Tell your provider about every medication and supplement you take and any history of diabetes, thyroid, or pituitary conditions.
COMPOUNDED MEDICATIONS ARE NOT APPROVED OR EVALUATED FOR SAFETY, EFFICACY, OR QUALITY BY THE FDA.
- 1Khorram O, et al. Effects of a GHRH(1–29) analog on serum IGF-1 and body composition in older adults: a randomized, placebo-controlled trial. Journal of Clinical Endocrinology & Metabolism. 1997.
- 2Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clinical Interventions in Aging. 2006.
- 3Van Cauter E, Plat L. Physiology of growth hormone secretion during sleep. Journal of Pediatrics. 1996.