PT-141 Nasal Spray concept package on a white background.Available now

PT-141 · metered nasal spray

Desire starts in the brain. Let’s wake it up.

PT-141 acts in the brain on desire and arousal—not blood flow. The spark that comes before the moment, in a needle-free nasal spray.

10 mg/mLconcentration
Nasal sprayneedle-free format
Refrigeratedstorage

The part before touch

You still love them. You just stopped wanting sex.

PT-141 is for the part that comes before touch—the interest, anticipation, and desire to begin. Bremelanotide acts on melanocortin receptors in the brain, not blood flow.

See the study scope →

The nasal presentation

A refrigerated 5 mL bottle with metered nasal-spray delivery.

See price and product details →
PT-141 Nasal Spray concept package showing the planned nasal spray form.

Bremelanotide injection trials

1,267 women. Two phase 3 trials. Twenty-four weeks.

The RECONNECT trials randomized premenopausal women with HSDD to 1.75 mg subcutaneous bremelanotide or placebo as needed. The measured outcomes were desire and distress related to low desire.

+0.35integrated difference in desire-domain change versus placebo
−0.33integrated difference in low-desire distress change versus placebo
24 weeksrandomized treatment period in both phase 3 trials
Read the phase 3 publication ↗

PT-141 nasal study

18

One 20 mg dose. Two in-clinic sessions.

In a double-blind crossover experiment, 18 premenopausal women received a single 20 mg intranasal dose and placebo in separate sessions. More participants reported moderate or high desire after bremelanotide; vaginal vasocongestion did not differ significantly.

The 5 mL bottle will pair its concentration with the pump's metered output and prescribed sprays per dose.

Read the intranasal study ↗

Bremelanotide injection safety

Not for uncontrolled high blood pressure or cardiovascular disease.

ContraindicationsThe approved injection is contraindicated in uncontrolled hypertension or known cardiovascular disease.
Common reactionsInjection trials most often reported nausea, flushing, headache, and vomiting.
Other label issuesThe label also covers temporary blood-pressure increases, heart-rate reduction, focal hyperpigmentation, pregnancy, gastric emptying, and naltrexone.
Read the FDA prescribing information ↗

Another needle-free format

PT-141 troches are available too.

A small troche that dissolves under the tongue or between gum and cheek.

See PT-141 Troches
PT-141 questions

What to know about the product.

PT-141 Nasal Spray

Ready to see whether PT-141 fits?

Complete a private online visit for clinician review.

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Intimacy results

Desire can feel present again—not scheduled around a product.

The PT-141 spray took a couple tries to get the timing right but once I did I noticed a real difference. I feel more interested and present instead of stuck in my head. The instructions were clear and my Rebody doctor answered my question without making it awkward.

Better than expectedVerified customer · More desire and presenceSeveral weeks

The PT-141 spray has helped with interest and I am initiating more often now. I did have a mild headache the first few times which made me nervous. I messaged my Rebody doctor and got a useful answer about timing and what to watch for. No major issues since.

Works but had a headache at firstVerified customer · More interest in sex6 weeks

I almost did not write a review because this is such a private topic, but maybe it will help someone else. My desire had been gone for a long time and it was creating distance between my husband and me. My Rebody doctor treated me with kindness and zero judgment, and the PT-141 spray has made intimacy feel natural and spontaneous again. The change in our relationship has been incredible. I am deeply grateful for the care I received.